March, 2020MSI Funded Study: Spices in a High-Saturated-Fat, High-Carbohydrate Meal Reduce Postprandial Proinflammatory Cytokine Secretion in Men with Overweight or Obesity
MSI Funded Study on Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females
Nieman DC, Cialdella-Kam L, Knab AM, and Shanely RA
The study hypothesized that supplementation with red pepper or turmeric would reduce inflammation and oxidative stress, and improve vascular function in free-living, overweight females with underlying chronic inflammation (CRP≥2 mg/l).
Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with red pepper (1 g/d) or turmeric (2.8 g/d) was tested for influences on inflammation and oxidative stress in 62 overweight/obese (body mass index≥27 kg/m2) females (40–75 years) with systemic inflammation (C-reactive protein, CRP≥2 mg/l). Overnight, fasted blood samples were collected pre- and postsupplementation, and analyzed for oxidative stress (F2-isoprostanes, oxidized low density lipoprotein), inflammation (CRP and seven inflammatory cytokines), and metabolic profiles using gas chromatography–mass spectrometry with multivariate partial least square discriminant analysis (PLS-DA).
Pre- to post-supplementation measures of inflammation and oxidative stress for both RP and TM did not differ when compared to placebo (all interaction effects, P>0.05), and global metabolic difference scores calculated through PLSDAwere non-significant (both spices, Q2Y<0.40).
These data indicate that 4-week supplementation with RP or TM at culinary levels does not alter oxidative stress or inflammation in overweight/obese females with systemic inflammation, or cause a significant shift in the global metabolic profile.