McCormick Science Institute

Activation of Extraoral Bitter Taste Receptors by Herbs and Spices in the Regulation of Incretin Signaling and Glucose Metabolism

Slavko Komarnytsky, Reham Mhawish, Charles Wagner

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MSI Team
June 2026 - Evidence suggests that activation of specific TAS2Rs by bitter phytochemicals can influence glucose transporter activity and stimulate the release of enteroendocrine hormones, including glucagon-like peptide-1 and cholecystokinin, thereby engaging established pathways involved in appetite regulation and glucose homeostasis.
This narrative review was developed through a summary of our work on the subject combined with an extensive search of scientific literature using databases including PubMed, Google Scholar, Web of Science, and Scopus accessed via institutional subscriptions at North Carolina State University, covering publications up to December 2025. Only peer-reviewed studies published in English were considered. The review concentrated on research published in the past 10 years. View Full Text

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