February, 2021MSI Funded Study: Acute Effects of Cinnamon Spice on Post-prandial Glucose and Insulin
Effect of spiced hamburger consumption on cardiovascular health in men with Type 2 Diabetes
Li Z, Henning SM, Zhang Y, Rahnama N, Zerlin A, Thames G, Tseng CH and Heber D
This study was designed to investigate whether consumption of a hamburger cooked with a polyphenol-rich spice mixture will reduce postprandial lipid oxidation and endothelial dysfunction in men with Type 2 diabetes.
Twenty-two type 2 diabetic subjects consumed burgers cooked with salt only (control burger) or with salt and spice mix (spice burger) in randomized order. The spice mix was comprised of cloves, cinnamon, oregano, rosemary, ginger, black pepper, paprika and garlic powder. The postprandial concentration of urinary malondialdehyde and nitrate/nitrite as well as the peripheral arterial tonometry score were determined.
Eighteen subjects completed the study. Postprandial serum glucose, insulin and triglyceride concentrations were similar in all subjects after control burger or spice burger consumption. Urine malondialdehyde excretion in mmol/g creatinine was reduced by 31% (P < 0.001) after consuming the spice burger compared with the control burger. Two hours after consumption of the burgers, the peripheral arterial tonometry score was significantly different between control burger consumption (9.7 21.5%) and spice burger consumption (+18.0 42.4%) (P = 0.025). Mean urinary nitrate/nitrite concentrations in urine collected during the 6 h after consumption of the control burger was 9.09 5.7 mmol/g creatinine, but 12.37 7.00 mmol/g creatinine after the spice burger (P = 0.053).
Adding a spice mix to hamburger meat prior to cooking resulted in a reduction in urinary malondialdehyde, an increase in urinary nitrate/nitrite and improvement of postprandial endothelial dysfunction in men with Type 2 diabetes. Therefore, cooking a hamburger with a polyphenol-rich spice mixture may lead to potential cardiovascular benefits in patients with Type 2 diabetes mellitus.